Advancing whole-brain, ground-truth-oriented neuroscience through neurotechnology innovation

We develop and apply optical and molecular tools to push toward ground-truth-level measurement and control of neural activity and signaling across the brain. Leveraging these tools together with biological experiments, we aim to reveal fundamental principles that govern brain function and neural computation, from learning and memory to brain aging and degeneration.

At the Rowland Institute, we currently focus on developing technologies that enable simultaneous imaging and perturbation of neuronal voltage dynamics at single-cell resolution across the entire vertebrate brain. We use larval zebrafish as a model system, which contains ~100,000 neurons in its translucent brain. [read more]