Advancing whole-brain, ground-truth neuroscience through neurotechnology innovation

We develop and apply optical and molecular tools to enable large-scale, ground-truth measurement and control of neural activity across vertebrate and mammalian brains. By integrating these technologies with biological experiments, we seek to uncover fundamental principles of brain function and neural computation, spanning processes from learning and memory to aging and degeneration.

Our current research at Harvard focuses on building platforms for simultaneous, whole-brain imaging and perturbation of neuronal voltage dynamics at single-cell and millisecond resolution. We use larval zebrafish as a model system, whose translucent brain contains ~100,000 neurons, allowing optical access at whole-brain scale. [learn more]